Recent progress of nucleic acid delivery system mediated by atelocollagen

Abstract

Recently, functional oligonucleotides, including siRNA and miRNA, draw much attention as candidates for novel medicine. Although siRNA and miRNA, which induce RNA interference, are powerful tools for regulating gene expression in vitro, it is not sufficient to apply them to clinical use, and efficient and safety delivery method is indispensable for practice. Atelocollagen-mediated nucleic acid delivery technology dramatically enhances the efficacy of siRNA and miRNA in vivo.
In this review, we describe the effectiveness of atelocollagen-mediated DDS by introducing recent reports on its application for siRNA or miRNA.