Drug Delivery System
Online ISSN : 1881-2732
Print ISSN : 0913-5006
ISSN-L : 0913-5006
Feature articles “Basic and Clinical Research on Brain-Targeted Drug Delivery Systems” Editor:Mariko Takeda
Brain-targeted drug and gene delivery by intranasal administration
Takanori Kanazawa, Yuuki Takashima
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Keywords: Intranasal brain delivery, micelles, cell penetrating peptide, brain tumor, siRNA delivery
JOURNAL FREE ACCESS

2013 Volume 28 Issue 4 Pages 318-327

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Abstract
Intranasal administration is a promising effective and non-invasive drug delivery to the brain without passing through the blood-brain barrier (BBB). Cell penetrating peptide-modified block copolymer micelles (MPEG-PCL-Tat) have potential for improvement of mucosal permeability and nose-to-brain transport efficiency. Here we review the advantages of our MPEG-PCL-Tat micelles for intranasal drug and gene delivery.
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© 2013 Japan Society of Drug Delivery System
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