Drug Delivery System
Online ISSN : 1881-2732
Print ISSN : 0913-5006
ISSN-L : 0913-5006
Feature articles "Antibody Delivery From bench to bedside" Editor: Yasuhiro Matsumura
Linker Technology in Antibody-Drug Conjugates for Cancer Treatment
Shino Manabe
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Keywords: antibody-drug conjugate, specifier, linker, spacer, diketopiperazine
JOURNAL FREE ACCESS

2013 Volume 28 Issue 5 Pages 406-411

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Abstract

Linker technology is important for antibody-drug conjugate development. Linker connects antibody and anti-cancer agent. The linkage between antibody-drug conjugate must be stable during blood circulation, yet the anti-cancer agent should be released at cancer lesion. In this manuscript, the aspect of various linkers and spacers will be described.

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© 2013 Japan Society of Drug Delivery System
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