In vivo fate of exogenously-administered exosomes

Abstract

Exosomes are membrane vesicles secreted from cells. Exosomes are endogenous delivery vehicles for biological molecules such as nucleic acids, proteins and lipids. Therefore, the development of exosome-based DDS is expected. The information on the tissue distribution of exosomes is prerequisite for the development of exosome-based DDS. However, sufficient data have not been obtained at present to systematically understand the tissue distribution of exosomes. Here we summarize the characteristics of the tissue distribution of exosomes and introduce our recent results on the subject.