Development therapeutic system by exosomal DDS of nucleic acid drugs

Abstract

A variety of cells release phospholipid membrane vesicles that are thought to play key roles in cell-cell communication, antigen presentation, and the spread of infectious agents. The membrane vesicles derived from the late endosomes called Exosomes. The various proteins, messenger RNAs (mRNAs) and microRNAs (miRNAs) carried by the exosomes to the cells in remote locations like a message in a bottle. The form to be protected encapsulated miRNA from ribonuclease (RNase) in the body fluid is ideal carrier for nucleic acid drugs. In addition, since the exosomes is constructed by self-component, the antigenicity and toxicity are expected to be low. It's extremely important property in carrier for drug delivery. This review presents an overview of the potential roles of exosomes with respect to carrier for miRNA delivery system.