2015 Volume 30 Issue 2 Pages 100-110
Two particle design technologies executing under ultra-cryogenic environment developed by authors are introduced. In the both technologies, the drug particles are generated in liquid nitrogen as a dispersing solvent, which is super cool liquid having boiling point atｰ196ｰC. These technologies are quite unique and unprecedented approach in the pharmaceutical industry and could be categorized according to the generation process of the drug crystals and/or particles; one is micronization technology via breaking-down process and another is crystallization technology via building-up process. In this article, the specific properties of liquid nitrogen are introduced at the beginning, and then the outline of these technologies effectively utilizing its specificity will be reviewed. As an example, the case studies for formulation development of the poorly water-soluble drugs are shown to apply these technologies to the pharmaceutical industry. In addition, the technologies under glacier temperature will be differentiated from the conventional one by showing the specific physicochemical and pharmaceutical behaviors of the resultant drug crystals and/or particles.
