Protection and Modification of Synthetic Oligonucleotides for the Development of Pro-drug Type Oligonucleotides

Abstract

The development of nucleic acid therapeutics has been of prime interest. However there are a lot of drawbacks to overcome for medical application. In this manuscript, we review the chemical approaches including chemical synthesis, protecting groups, modifications and conjugation with functional residues to overcome those problems of oligonucleotides and discuss future development of nucleic acid therapeutics.