Abstract
Cancer immunotherapy is an approach to treatment to effectively induce anti-tumor immunity to tumor tissues. Recent implementation of cancer immunotherapy approach to cancer treatment has been employed. In this study, we have attempted to develop a DC vaccine therapy using TECs isolated from solid tumor tissue as vaccine antigens. As a result, immunotherapy targeting tumor blood vessels showed the efficacy for tumor growth and metastases. However, vaccination using DCs pulsed with TECs did not inhibit physiological angiogenesis. Additionally, DC vaccination using TECs derived not only from the same tumor tissue but from a different type of tumor also suppressed metastasis. These results thus show that cancer vaccine therapy targeting TECs is an effective therapy against angiogenesis in several types of cancer, but does not affect normal blood vessel growth.
