Abstract
The oral route is considered to be most convenient for administration of drugs to patients. However, solubility limitations to oral drug delivery are frequently encountered in the development of commercial products. In recent years scientific and technological advancements have been made in the research and development of rate-controlled oral drug delivery systems by overcoming physiological adversities. Several prodrug esters have been reported to improve the oral absorption of penicillin, for example pivaloyloxymethyl ester, acetoxymethyl ester, propionyloxymethyl ester and phthalidyl ester. Carrier or delivery systems such as liposomes and microspheres have been developed for the sustained delivery of antibiotics. In this article, we introduce the characteristics of the oral DDS for antimicrobial therapy.
