Abstract
Mucosal tissues are constantly exposed by exogenous materials including various pathogens and thus they invade into our body through mucosal tissues. Mucosal vaccine is an effective strategy against mucosal infectious diseases, and has been already clinically used. Unlike injectable vaccines, mucosal vaccines induce immune responses at mucosal as well as systemic compartments. Because administration of protein vaccine alone to mucosal tissues dose not induce sufficient immune responses, mucosal vaccines require antigen delivery system to deliver the antigen to mucosa-associate lymphoid tissues for the induction of effective immune responses. In this review, we focus on the development of vaccine delivery system for the prospective mucosal vaccine.
