2018 Volume 33 Issue 5 Pages 372-376
Exosomes are membrane vesicles composed of lipid bilayer with diameter of approximately 100 nm and are released from various types of cells. Exosomes work as endogenous intercellular delivery vehicles. Intercellular delivery by exosomes has been demonstrated to be related to the development, progression and metastasis of gastrointestinal cancer. On the other hand, exosomes, endogenous delivery carriers, can be effective DDS targeting gastrointestinal cancer. Here, we describe problems in the development of exosome-based DDS and solutions for the problems and introduce reported examples of exosome-based DDS targeting gastrointestinal cancer.
