2019 Volume 34 Issue 4 Pages 236-242
Lack of efficacy, unacceptable safety, or unpredictable toxicity remain the main cause of attrition in drug discovery and development researches in recent decades. Microphysiological systems (MPS) containing organ-on-a-chip may have a potential to be a clinically relevant tool for better understanding of human physiology through microfluidic cell culture systems connecting living engineered human cells or tissue engineered 3D organs in a controlled microenvironment. This article describes advanced technologies and MPS products in oversea countries, overview of national MPS project focusing on user-driven MPS development, and future prospects as follows.
