Abstract
mRNA therapeutics is defined as a new type of nucleic acid medicine by direct administration of synthesized mRNA into the body for therapeutic and prophylactic purposes. Since mRNA is extremely unstable outside the cells, DDS plays a crucial role for delivering the mRNA into the target cells in the body. LNPs have been most frequently used for mRNA delivery, however, it is still difficult to target various tissues and organs other than the liver. We are developing an original DDS, polyplex nanomicelle, which is advantageous in its excellent capacity of tissue penetration after local administration, as well as the low toxicity due to the biodegradability of the nanomicelle. In this article, I would like to introduce the system of polyplex nanomicelle, and the recent studies using the nanomicelles for administering mRNA therapeutics for disease treatment.
