Abstract
RNA signaling pathways are transduced via microvesicles or exosomes in cellular population. Wide varieties of RNA such as mRNA, microRNA, circular RNA, and long non-coding RNA play different roles in the signaling pathways. Treatment-resistant cancer has properties such as epithelial-mesenchymal transition（EMT） or cancer stem cells（CSCs）, and signaling pathways mediated by microRNAs in exosomes alter corresponding to the surrounding environment in cancer metastasis. In this review, RNA signaling pathway in cellular population via exosome is focused.
