Abstract
In the case of mRNA drugs, therapeutic effects are caused by proteins produced from mRNAs rather than mRNAs themselves. Thus, a system to regulate therapeutic protein production from mRNAs can function as a kind of drug delivery system. Regulation of protein production from mRNA drugs is more difficult than that from plasmid DNAs or viral vectors as mRNA drugs cannot utilize transcriptional regulatory sequences. However, various translational regulator systems have recently been developed. In this review, we introduce these translational regulator systems including our own studies.
