Abstract
For mRNA delivery to the kidney, the choice of administration route and vector is very important due to the structural characteristics of the kidney. Furthermore, it is necessary to devise a combination of physical methods to improve the transduction efficiency. The transfeted cells depend on the delivery methods. Therefore, it may be useful to identify the transfected cells and evaluate their expression distribution in the development of therapeutic strategies. Since there are few reports in the field of mRNA delivery to the kidney, this review describes gene/nucleic acid delivery, focusing on administration routes and vectors, and introduces mRNA delivery to the kidney.
