Abstract
AzimycinⓇ ophthalmic solution 1％ is the only macrolide antibiotic ophthalmic solution containing azithromycin hydrate as the active pharmaceutical ingredient in Japan. Azithromycin is a drug characterized by good tissue penetration and stability at acidic pH. In addition, the formulation technology of AzimycinⓇ ophthalmic solution 1％ used the ophthalmic Drug Delivery System technology “DuraSiteⓇ” that contains polycarbophil and other ingredients. The effect of polycarbophil increases viscosity and mucous membrane adhesion. The effect improves drug retention on the ocular surface and intraocular penetration of the drug as well. The drug characteristics and formulation technology enable the treatment of ocular infections with fewer number of dosing per day than the number of dosing of other antibacterial ophthalmic solutions. It expects to improve patient adherence.
