Abstract
Mucosal vaccines, in which vaccination is administered through mucosal （e.g., oral and nasal） routes, are attracting attention. Applications of delivery system and adjuvant are prerequisite for the practical use of mucosal vaccines. Delivery systems based on polymers, nanogels, lipids, and microbial components can promote delivery efficacy and extend the retention of vaccine antigens into mucosal tissues, resulting in the enhanced vaccine efficacy. In addition to delivery functions, adjuvant functions that can control immune responses such as activation of antigen presenting cells and induction of appropriate T cell responses are required to develop more effective vaccines. Here, we would like to introduce the development of next-generation delivery systems that can impart appropriate functions to various vaccine targets.
