Abstract
The blood-brain barrier（BBB） constitutes the interface between the blood and the brain to prevent the invasion of pathogens and chemical substances. BBB also prevents the transport of drugs into the brain. Impairments of its barrier functions have been reported in case of some CNS diseases. In vitro BBB models are useful to understand the effects of CNS diseases on barrier functions and develop the novel CNS drugs. Brain microvascular cells differentiated from human iPS cells are used for in vitro BBB models to apply to the study of drug disposition, disease models, and drug delivery systems. Finally, the problems and improvements of current BBB models are mentioned.
