Abstract
Glycans are present on all cell surfaces and serve as intermediaries for communication with the outside world. Glycan-protein interaction is the central interaction, and various combinations of glycan-protein interactions have been found. The application of these interactions to drug delivery systems has been actively pursued for almost 40 years. In this article, we trace the history of research to date and review the research trends by organizing the research into two categories: research targeting cellular and tissue glycans and research targeting sugar-binding proteins （lectins）.
