Abstract
As an expert in protein chemistry, Dr. Maeda conducted a wide range of research, including not only cancer treatment, but also cancer prevention, viral and bacterial infections, and left a great legacy of accomplishments. This article will focus on EPR effects, as they are introduced in his other books. Although the EPR effect has been proven worldwide in experimental mouse tumors, Dr. Maeda and the author have been discussing for a long time the fact that it is not widely accepted in clinical solid tumors. In order to make the EPR effect a sound theory in clinical practice, Dr. Maeda adopted a strategy to enhance tumor vascular hyperpermeability, which is a key factor in the EPR effect. The author adopted a strategy of adding cancer stroma targeting therapy to the EPR effect. Professor Maeda and the author believe that from the perspective of solid tumor treatment, the difference between cancer tissues and normal tissues defined by the EPR effect is more important than the molecular biological differences between cancer cells and normal cells.
