Modeling & Simulation strategies for Bispecific Antibody Development

Abstract

Conventional antibodies bind to a single epitope or antigen（Target）. On the other hand, bispecific antibodies bind to two targets. In drug development, Modeling & Simulation（M&S） has been implemented the development strategies. M&S was using as an internal decision-making tool in the company, and information was rarely disclosed. Recently, some articles have reported “setting initial dose, exposure-response, to avoid adverse event” for bispecific antibody using M&S. In this article, introduce two types of development product, focusing on the purpose of M&S and how to utilize existing data.