Development of Designer Cells by Chemical Approach

Abstract

We have recently developed the concept of “designer molecules,” which are capable of adding various new functions to cells. Designer molecules consist of a “cell anchor moiety” for immobilization to the cell membrane, a “functional moiety” for adding function, and a “stealth moiety” for evading immune cells. As proof of concept, we synthesized a designer molecule that allows target-directionality and subsequently demonstrated its efficacy. Designer molecules are expected to be applied as a unique strategy that can add various functions to cells through chemical approaches.