Abstract
In the drug discovery and development process, the use of experimental animals is crucial for evaluating pharmacokinetics, safety, and efficacy of drug candidates. There has been a growing demand for alternative methods from the perspective of animal welfare. Therefore, to enhance the extrapolation of preclinical research to humans, there is an increasing need for new in vitro models that can replicate human physiological responses. One of the promising technologies is the microphysiological systems（MPS）, which is expected to improve the success rates of drug development. This review outlines the impact of MPS on drug discovery and development and the needs for its utilization from the perspective of the pharmaceutical industry. Furthermore, examples of the application of MPS in drug delivery system research targeting the central nervous system will be introduced.
