Application of proteomics analysis to drug delivery system research

Abstract

Drug Delivery Systems (DDS) enhance therapeutic efficacy and minimize side effects by efficiently and selectively transporting drugs to target sites within the body. For example, in cancer therapy, selectively transporting drugs to cancer cells reduces the impact on normal cells, thereby mitigating side effects. In drug therapy for central nervous system disorders, a major challenge is overcoming the blood-brain barrier, which acts as a barrier to brain penetration, and enabling drug entry into the brain. When considering drug therapy for pregnant women, it is necessary to deliver drugs selectively to the mother’s target tissues while minimizing drug transfer to the fetus. Overcoming these challenges requires an understanding of biological mechanisms, such as cell membrane transport mechanisms and intracellular signaling pathways. This paper introduces the potential application of proteomics technology to DDS research with an example of comprehensive phosphoproteomics of synaptic proteins in a neurological disease model. The comprehensive and quantitative proteomics can provide a molecular basis for designing next-generation DDS technologies.