Abstract
For the treatment of peritoneal carcinomatoses, we have developed a new dosage format, which comprises cisplatin microcrystals suspended in oil (CDDP-Oil). The acute toxicity of intraperitoneal CDDP-Oil was studied in mice. The LD50 value was 30.3 mg/kg in terms of cisplatin, which was 1.79 times that of a cisplatin aqueous solution (CDDP-Sol) of 16.9 mg/kg. There were no differences of the toxic symptoms between these two dosage forms, and any addisional side effects of cisplatin were not seen by the change of dosage form. However, the severity of body weight loss in the mice given CDDP-Oil was less than the mice given CDDP-Sol. We concluded that acute toxicity of cisplatin was redused by the change of dosage form.
