Pathological study for the acute toxicity of cisplatin microoystals suspended in oil by intraperitoneal administration in mice

Abstract

Pathological changes were compared between two dosage formulations of cisplatin microcrystals suspended in oil (CDDP-Oil), and cisplatin aqueous solution(CDDP-Sol), by intraperitoneal administration in mice. Main toxic findings such as decreasement of the organ weights and histopathological degenerations were seen in the kidney, liver, and hematologic tissues of the spleen, lymph nodes and bonemarrow. Those changes were more heavy in mice died by the toxicity than in mice surviving during the observation period. Thus, the toxic changes were principally similar in the two dosage formulations, and there were no aditional toxic effects in the CDDP-Oil.