Abstract
We have tried the hepatic artery chemoembolization therapy for hepatic tumor-bearing rats using liposomes containing adriamycin as a material for embolization and found the enhanced therapeutic effect against W256 carcinosarcoma-implanted rats. In this report, we discussed the therapeutic effect against the primary hepatic tumor induced by dietylnitrosamine. Any embolization with liposomes consisting of dipalmitoyl-phosphatidylcholine alone was not observed on the primary liver cancer-bearing rats. It is contrasted with W256 implanted model. Polysaccharide modified liposomes made it possible to form embolization. Especially, chondroitin sulfate-modified liposomes showed the high accumulative property of entrapped adriamycin into the hepatic tumor of the rats and significantly increased their life time.
