Abstract
New specific therapy targeting cancer cell was reviewed. The history of tumor markers (CEA, AFP) and the development of antibody from conventional polyclonal antibody to monoclonal antibody including chimeric or humanized antibody were introduced. Trials using antibody alone, antibody conjugated with drugs and antibody labelled with radioisotopes were summarized. Receptors on cancer cell membrane could be a good marker of cancer available for the diagnosis and therapy. Finally gene therapy was introduced and it was emphasized that new drug (gene) delivery system will be necessary for the development of practical gene therapy of cancer.
