A novel transdermal preparation of morphine and possibility of the clinical application for cancer pain

Abstract

A novel transdermal preparation was applied for the cancer patient who were complaining cancer pains to test the possibility of the future clinical application. Four patients with cancer pain were applied this new preparation on their chests and were examined amelioration of the cancer-related pain and the adverse effects on the skin. The patients whose pains had been controlled by MS-Contin preparation were entered in this clinical study, applying this new transdermal preparation after stoppoing the use of MS-Contin preparation for 24 hours. In most cases, amelioration of cancer pain was found and the adverse effects on the applied sites were minimal. Therefore, it seemed possible to test this preparation for the relief cancer pain clinically in the future.