Abstract
There is no quantitative analysis on the relationship between antitumor effect and optimum conditions of liposomes as drug carriers. We have developed a physiological model which incorporates a cell kill kinetic model for the antitumor effects of free and liposomal DOX in mice. Antitumor effect predicted by this model showed an optimum rate of drug release from liposomes (∼10hr in half life) and this prediction was varified by animal experiments in vivo. There was a good relationship of antitumor effects between simulations and experiments, which validates our model. This model will provide useful information for optimization of drug carriers for anticancer drugs.
