Abstract
The present status of the drug delivery system in the treatment of cancer was reviewed. Chemoembolization using mitomycin C entrapped in microcapsules of ethylcellulose for renal cell carcinoma and hepatocellular carcinoma were presented. Also, SMANCS dissolved in oily contrast medium Lipiodol for the treatment of hepatocellular carcinoma and chemoembolization using DSM(Degradable Starch Microsphere) were introduced. As an example of DDS for the slow release of drugs, the process of the development of copoly(DL-lactic/glycolic acid) microsphere leuprin was introduced. It is believed that immunotargeting therapy using antibody as a carrier of drug, biodegradable carriers, liposome technology and micromagnetite will be developd rapidly in 21st century. The Japan Society of Drug Delivery System will make a great contribution to the development of new DDS in the future.
