Abstract
The historical aspects of the development of cancer therapy using antibodies were considered. And cancer treatment trials using antibody conducted in USA were introduced. At present the key antibody in the treatment of cancers is herceptin that bound to HER-2/neu. Many kinds of chemotherapeutic regimen had been combined with antibody therapy. Also some unique antibodies other than herceptin had been developed and clinical studies were conducted. The number of clinical study using antibody in Japan is still very small.
