Abstract
The problems of cytotoxic agents have been attributed to their low therapeutic indices and limited efficacy due to the non selective nature of their molecular targets and their inability to accumulate selectively in cancer tissues. Therefore, there is an urgent need to develop ways by which cytotoxic drugs can be selectively targeted to tumor tissue to allow them to act effectively against the cancer cells in the scene. The role of a drug delivery system(DDS) has drawn attention in this connection, Passive targeting is based on the so-called enhanced permeability and retention (EPR) effect. To use the EPR effect to full advantage, several techniques have been developed, namely, modification of the structures of drugs and development of drug carriers. In this review article, the results of preclinical and clinical studies of micelle-forming polymeric drug were described.
