Abstract
Antineovascular therapy aims to eradicate tumors by delivering cytotoxic agent to angiogenic vessels. The concept is different from tumor dormancy therapy by using angiogenesis inhibitors. For the purpose of antineovascular therapy, we isolated angiogenic vasculature-targeting peptide by a phage-displayed peptide library, and developed the peptide-modified liposomes. We demonstrated that the targeted liposomes containing cytotoxic agents effectively suppressed tumor growth through disrupting angiogenic vasculature. In this review, we summarize angiogenesis inhibitors, relationships between angiogenic vessels and liposomal anti-cancer agents, and usefulness of antineovascular therapy.
