Abstract
Recently, resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) or penicillin-resistant Streptococcus pneunioniae(PRSP) is widely prevalent. Thus, the new treatment rather than antimicrobial agents has been needed. The gene therapy that expresses inflammatory cytokines is currently under development. The transient transgenic expression of IFN-γ or TNF-α may be of potential therapeutic benefit in bacterial infection. Several investigators have suggested the efficacy of antisense nucleotide against Influenza virus. RNA interference(RNAi) is a process by which double-stranded RNA (dsRNA)directs sequence-specific degradation of messenger RNA (mRNA). The usefulness of RNAi against severe acute respiratory syndrome(SARS) virus is recently reported. Short-interfering RNA may be a new strategy against infectious diseasesin the near future.
