Abstract
Endovascular embolization for cerebral aneurysm with platinum coils has become an alternative therapy to surgical clipping. However, recent clinical trials have demonstrated disappointing long-term results for patients treated with the conventional platinum coils. The problem includes recanalization and the rupture of giant and large-neck aneurysm. This is mainly because thrombosis of aneurysm induced by the platinum coil is often unstable. Basic fibroblast growth factor (bFGF) is an ideal growth factor to use for aneurysm healing. We have reported that the controlled release of bFGF with a gelatin hydrogel stimulated the formation of fibrosis in a rabbit aneurysm, resulting in aneurysmal obliteration. The current state of treatment using endovascular surgery for cerebral aneurysm, the problem and the view in the future are described.
