Improvement of transmucosal absorption of drugs in drug delivery system (DDS)

Improvement of transmueosal absorption of protein and peptide drugs by cyclodcalrius

Abstract

A number of therapeutically important protein and peptide drugs have been actively developed. However, there are considerable hurdles to be overcome before practical use can be made of these drugs due to chemical and enzymatic instability and poor absorption through biological membranes. Many attempts have addressed these problems by chemical modifications or by delivery systems for these drugs. This review outlines the current application of cyclodextrins in enhancement of transmucosal absorption for these drugs.