Improvement of transmucosal absorption of drugs in drug delivery system (DDS)

Skin-penetration enhancement and control of topically applied drugs

Abstract

Recently skin has been much attention as a site of administration of systemically active drugs. Transdermal route offers a number of potential advantages, e.g., avoidance of first-pass liver metabolism and continuous and consecutive long term drug therapy. However, the skin permeation of therapeutic drugs was extremely low, so that approaches to appropriate enhancement are necessary to be a useful delivery systems. Physical and chemical technologies are utilized to improve skin permeation of drugs. Recent advanced technologies would enable transdermal delivery of macromolecules such as peptide, protein, and oligonucleotides as well as low organic drugs.