Abstract
We can use controlled-release morphine derivatives such as MS Contin, MS-Twicelon, Morphes, Kadian and P Guard in clinical situation. The former three drugs were administered twice a day and the latte two drugs were administered once a day. And we can use Oxycontin, which is controlled-release oxycodone (oxycodone is synthesized from thebaine abstracted from opium) administered twice a day. These 6 controlled-release opioids are indicated to cancer pain. When we use these controlled-release drugs we must use quick acting morphine as rescue. On the other hand, we can use controlled-release NSAIDs and prodrugs of NSAIDs. The former includes Voltaren SR Capsules and Inteban SP and the latter includes acemetacin, indomethacin farnesil, proglumetacin maleate, ampiroxicam and loxoprofen sodium.
