Abstract
We developed a new apparatus to inject anticancerous drug into the peritoneum by high pressure water jet. The principle of this method is that minute water particles containing high-dose anticancerous drugs developed by nozzle, which connected the water pump, are administered to the peritoneum. After the injection of Cisplatinum (CDDP) using this apparatus, pharmacokinectics of CDDP was studied. The platinum concentration of peritoneal tissue in treated rats was 5 to 35 times larger than that of control rats, received intraperitoneal injection of the same dose of CDDP. In addition, the free CDDP in peripheral blood could not be detected thoughout the experiment. Three cases of gastric cancer with peritoneal dissemination were treated by this method. Two of them disclosed the complete disappearance of ascites. These results indicate that this novel method is useful to treat the peritoneal dissemination of various carcinomas.
