徐放性interleukin-2 mini-pellet製剤のLAK細胞養子移入療法への応用 ―マウスMeth A腫瘍に対する抗腫瘍効果―

藤原 俊義; 阪上 賢一; 松岡 順治; 塩崎 滋弘; 内田 晋; 河村 武徳; 高須 伸治; 森崎 太; 斉藤 信也; 大岩 敏彦; 羽井佐 実; 稲垣 優; 折田 薫三

doi:10.2745/dds.3.437

Antitumor effect of interleukin-2(IL-2)mini-pellet plus LAK cells on Meth-A sarcoma in mice

Toshiyoshi Fujiwara, Ken-ichi Sakagami, Junji Matsuoka, Shigehiro Shiozaki, Susumu Uchida, Takenori Kawamura, Shinji Takasu, Futoshi Morisaki, Shinya Saito, Toshihiko Owa, Minoru Haisa, Masaru Inagaki, Kunzo Orita

Author information

Toshiyoshi Fujiwara
The First Department of Surgery, Okayama University Medical School
Ken-ichi Sakagami
The First Department of Surgery, Okayama University Medical School
Junji Matsuoka
The First Department of Surgery, Okayama University Medical School
Shigehiro Shiozaki
The First Department of Surgery, Okayama University Medical School
Susumu Uchida
The First Department of Surgery, Okayama University Medical School
Takenori Kawamura
The First Department of Surgery, Okayama University Medical School
Shinji Takasu
The First Department of Surgery, Okayama University Medical School
Futoshi Morisaki
The First Department of Surgery, Okayama University Medical School
Shinya Saito
The First Department of Surgery, Okayama University Medical School
Toshihiko Owa
The First Department of Surgery, Okayama University Medical School
Minoru Haisa
The First Department of Surgery, Okayama University Medical School
Masaru Inagaki
The First Department of Surgery, Okayama University Medical School
Kunzo Orita
The First Department of Surgery, Okayama University Medical School

Keywords: interleukin-2, LAK cells, adoptive immunotherapy, Meth-A sarcoma

JOURNAL FREE ACCESS

1988 Volume 3 Issue 3 Pages 437-443

DOI https://doi.org/10.2745/dds.3.437

Details

Abstract

We have evaluated the antitumor effect of IL-2 mini-pellet on the therapy of murine Meth-A sarcoma. After the administration of IL-2 mini-pellet containing 1×10⁶u of IL-2, the serum IL-2 activity was detectable for 72 hours. The s. c. administration of IL-2 mini-pellet and the i. v. injection of LAK cells was effective in inhibiting the tumor growth and could also prolong the survivals. The lytic activites of splenocytes against YAC-1 cells and JTC-11 cells after the administration of IL-2 mini-pellet were augmented. In histological examination on day 7 after the administration of IL-2 mini-pellet, a lot of lymphocytes were invased into tumor tissues. These results suggest that IL-2 mini-pellet can be applied to the adoptive immunotherapy using LAK cells.

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