Abstract
For the purpose of enhancing selective transfer of anticancer drug into the tumor and the regional lymphnode in esophageal cancer chemotherapy, we aimed at the administration of the anticancer drug into the lumen of the esophagus. We have reported the effectiveness of using lipid-surfactant mixed micelles(MM) as an absorption promotor and a dextran sulfate(DS)as a lymphotropic carrier. In this study, we observed the antitumor effect of this system. An experimental model of esophageal cancer was made by implanting VX2 carcinoma endoscopically into the esophageal wall of rabbits. We treated these rabbits with distilled water alone, peplomycin(PEP) with distilled water, PEP with MM, and PEP·DS ionic complex with MM, respectively. The antitumor effect of each group was evaluated by the histological findings and the weight of metastatic lymphnodes. The administration of PEP·DS complex with MM showed the good antitumor effect not only in the primary tumor of esophagus but also in the metastatic lymphnodes. Consequently, it was recognized that the antitumor effect of PEP was enhanced by using MM together with DS and we expect the clinical application of this system.
