Abstract
Selective increasing of drug delivery to tumor tissue is essentially required for enhancement of effects in cancer chemotherapy as same as selection of sensitive drugs. Based on the functional difference between tumor and normal tissue in microcirculation, marked and selective increase of blood flow in tumor was observed by angiotensin induced hypertension. Since 1978, clinical application has been carried out as IHC. In an experimental result, increase of life span of tumor bearing rats was obtained in the MMC under AII hypertension treatment group comparing with usual MMC i. v. group at each same dose, It suggests that total dose of drug administered obtaining the similar effect may be reduced in comparison with usual i. v. administration. According to the clinical results of IHC, dose intensity (DI) was calculated in induction and maintenance chemotherapy courses. DI of ADM was 7.2±2.8 mg/sq m/w for induction and 2.2±1.2 mg/sq m/w for maintenance course, and 5-FU was 540.2±341.6, 132.9±174.3 mg/sq m/w, and then MMC was 1.2±0.5, 0.2±0.1 mg/m2/w, respectively. Although these DIs, futhermore, must he compared with others in usual i. v. chemtherapy, selective enhancement of drug delivery to tumor tissue would be possible either to increase effects or reduce accumulation of toxicity in the hosts.
