Abstract
Purified polyclonal or monoclonal antibodies to tumorrelated antigens have been conjugated with anti-cancer drugs or toxins. Radiolabeled antibodies are also included in this paper. Various conjugation methods are used to make stable conjugates. The effect of the conjugates on target tumor cells or tissues have been investigated in vivo as well as in vitro mostly in experimental tumor sytems and specific inhibition of tumor growth has been observed in these systems. Clinical application of the targeting chemotherapy has been revealed that the approach will be the promising method for the treatment of early cancer or residual micrometastasis after the resection of the primary tumor tissues.
