Abstract
Accumulation and antitumor effect of anti-ferritin antibody on the liver cancer implanted in nude mice were studied. Human hepatocellular car-cinoma strain (HC-4) was implanted on the back of Balb/c nu/nu mice. The following day after implantation, 131-I labeld antiferritin antibodies were administered intraperitoneally. Thirds and 7th days after administration, whole body scintigraphy was done and on the 10th days rats were sacrificed to measure the relative radioactivities of each organs. Furthermore, tumor growth rates were calculated. As the results, all of mono and polyclonal antibodies were well accumulated to the tumor tissue both of on day 3rd. and day 7th. Tumor growth curves were depressed in the groups of antibodies injection compared with normal IgG group. In conclusion ferritin may have a possibility to be a target of imaging of human hepatoma and targeting immunotherapy.
