Abstract
A newly developed drug delivery system, ultrafine particles of activated charcoal is introduced and 2 types of them are examied in absorbability of MMC and ability of transport of MMC to lymph system. One is Mitsubishi CH-40 and the others Mitsubishi 1500AA. The sizes of each prinary particle of them are about 20 nm in diameter. As for the absorbability concern, much better one is observed to MMC in 1500AA than in CH-40. Serial samplings of lymph of thoracic duct by canulation and serial blood samplings of peripheral vein are done in canine to know the dynamics of lymph-blood systems through those clearance curves of MMC. Clearance K and half value period T1/2 are calculated from the formula ; C(t)=C(t0)e-kt. Comparing to that of MMC-saline, the activated charcoals are proved to have good abilities of transport MMC to lymph systems and in 1500AA charcoal, MMC is retained much longer time than in CH-40. Congestive effects of the lymph systems are observed by ligation of the thoracic duct in CH-40 with 25% prolong of T1/2. In conclusion, these drug delivery systems are suitable for the targeting chemotherapy of lymphnodes metastasis of colorectal cancer, especially by 1500AA activated charcoal.
