Development of evaluation method for drug disposition in tumor using tissue-isolated tumor perfusion system

Abstract

New method to evaluate drug disposition characteristics in tumor was developed employing rat tissue-isolated Walker 256 carcinosarcoma perfusion system. Mitomycin C and its lipophilic and macromolecular prodrugs used as a prototype of targeting DDS were administered from the arterial side by bolus injection or constant infusion. By applying moment analysis and so on, disposition characteristics of these drugs in tumor were elucidated and discussed in relation to their physicochemical properties, These experimental system was thus suggested to be useful in evaluating drug disposition in tumor.