Investigation on the intraoperative intraperitoneal administration of Mitomycin C adsorbed on activated carbon (MMC-CH1500A) for severe peritoneal dissemination (P₃) of gastric cancer

Abstract

We investigated the therapeutic effects of activated charcoal microparticles(CH) (specific surface area=1, 480 m²/g, diameter=20 mm), which have high capacity to retain anti-cancer agents, on perconeal dissemination of gastric cancer in 7 cases without liver metastasis, the primary tumor of which were resected surgically. The composition of MMC-CH was as followed : MMC : CH =1 : 8.3 (weight ratio). MMC solved into saline solution was shaked to mix up with 2% polyvinylpyrrolidone K-30 containing CH (50 mg/l ml saline), and the mixture was scattered into the abdominal cavities just before the closure of abdominal walls. MMC was given at 20 mg to 2 cases, at 30 mg to 3 cases, at 40 mg to one case and at 50 mg to one case respectively. The survival rate of the MMC-CH administration group, calculated by Kaplan-Meier's method, was higher than that of the control group