Abstract
Pharmacokinetics of ADM-OXD were studied by HPLC method in rabbits and Sarcoma 180 bearing mice and compared with those of ADM. (1) The plasma level of ADM-OXD was high and persisted for a long time. The drug level in the blood cells was lower than that in the plasma. (2) The tissue level of ADM-OXD was not so high in an early time after administration, but remained for several days. ADM-OXD distributed highly in tumor tissues as compared with ADM administered mice. ADM-OXD liberated free ADM in normal and tumor tissues. (3) ADM-OXD was excreted predominantly into the urine. (4) The liver-injured mice treated with CCl4 showed analogous drug level in the plasma and tumors, while lower level in the liver, as compared with control mice.
